SSRI's & St. John's Wort
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In this past Sunday's Parade Magazine an article stated that a person should not take St. John's Wort if they are taking an SSRI. Has anyone had any experience with this combination?
Answer:
I would not recommend it, since it increases your chances of devloping serotonin syndrome. My wife wanted to switch from Zoloft to St. John's Wort, and her doctor put her on half a dosage of each until the Zoloft ran out, then full dose of St. John's Wort. She seemed fine while she was taking both, but a week or two after she was on St. John's Wort only, she started getting insecure again, and nervous and oversensitive, and cried. The doctor put her back on Zoloft and she's been fine. She's been taking Synthroid for her hypothyroidism far longer than antidepressants, and the doctor also checked her thyroid and her tsh was high, which would give the symptoms I mentioned. The thing is, here thyroid had been normal for six to eight months before this episode. By the way, St. John's Wort is an SSRI too. what little i know about pharmacology will blatantly show here, but here goes. a drug's degree of "bioactivity" delineates its effectiveness. over the counter schnive like melatonin and sjw are NOT, as far as i know, analysed and segregated accorcingly-the standards for it dont exist yet. therefore there could be MAJOR fluctuations in what one takes in each dose. Yes, with herbs, there's no real way to guarantee that what you're getting is in a stable dose, at least with our pharmacological friends, you know 10mg means 10mg, notice that the labels on these herbal things say things like "contains at least 3mg of such and such". This doesn't make me too comfortable. I normally don't have problem with herbal stuff, I use them myself. But there appears to be a problem with SJW in that in the face of really severe onslaughts, it doesn't hold up. I really don't think SJW qualifies as an SSRI, either. If we're gonna get liberal with the term, I suppose you could argue that fenflinuramine(?) is an SSRI, too. Uh uh. Many herbs are now standardized to have a certain amount of the active ingredient. If you're worried about whether you're getting exactly what it says on the label, buy from the better companies like Enzymatic Therapy and Solgar. For instance my Ginko from the Vitamin Shoppe (which, by the way, has an 800# and offers good quality for a reasonable price) says, "60 mg. of Ginko Biloba leaf extract concentrated and standardized to provide 24% ginko-flavoglycosides with 6% ginkgogolides-bilobalide . . . "
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