Why Do Antidepressants No Longer Work??
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I have had problems with depression for years now and in the past, antidepressants always worked and I was able to function again. I am 41 now and have tried many different antidepressants and even mood stabilizers and nothing seems to take away from my depression. I am on disability, have been for two years. I want my life back so bad and be able to function again.
Answer:
Can you let us know what antidepressants you've taken, both in the past and recently? Chances are you haven't tried them all, esp. MAOIs (which tend to work when others don't). It happens. It happened to me too and I've asked the same questions to myself. The brain just adapts to the drug, or maybe what happens is that people take them when they're really depressed and they work then but when their back to normal or even better they stop working, maybe it's because your brain has to be in that major depressive type of state again to respond to the medication. I wonder if I took the medication that worked for me before I ever got majorly depressed if it would've worked for me then. All we can do is just keep trying different medications and cross our fingers that one will work again and then cross our fingers again that it won't stop working. This is draining stuff and hopefully within a decade or so PET scan machines or something similar will be able to tell us what exactly is happening to make the drugs stop working. According to some, the loss of efficacy occurs when the patient is bipolar. I don't know how much credence this assertion warrants, but I thought I'd let you know. You might try looking at Dr. Bob's Psychopharmacology Tips and submitting a query there. It has been hypothesized by Don Klein and others that what looks like decreased antidepressant effectiveness is really a state of akinesia resulting from depletion of dopamine with continuing use of the SSRIs. Based on this understanding one can treat the apparent fall-off in SSRI effectiveness with DA agonists such as bupropion, amantadine, methylphenidate, dextroamphetamine, etc. I have done this on many occasions, often with excellent results.
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