Zoloft: Sexual Side Effects And Increased Depressed Mood
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I have lowered my dose to 100mg in the hope of sexual fullfillment !...... Still no luck and I am wondering if this is what is causing the return of my depression..... Does anyone know of a drug that works without the sexual side effects ??
Answer:
I, too had the same problems with the inability to orgasm on Zoloft, when I hit the 200mg and 250mg dose. At the lower doses it was just more difficult. While most of the SSRI's may cause sexual dysfunction, I really haven't had that problem unitl I arrived at Zoloft. I've been on many the last 5 years such as Paxil, Effexor, Serzone,Wellbutrin, Remeron, Prozac to name just a few. Talk to your doctor about the fact that the Zoloft is no longer working for the depression (and discuss the sexual side effects if you so desire) and ask for a new SSRI. It's not unusual for them to stop working after a period of time. For me they usually only last for 6-9 months. I envy thoses who say they have been on a single AD for 3 years, say. As for the difficulty to have an orgasm; it certainly was enough to make me more depressed. There are lots of relatively safe, natural, and "nonantiorgasmic" alternatives, like exercise, meditation, and cognitive-behavioral therapy. Among natural pills, St. John's wort is associated with very very few anecdotal reports of erectile or orgasmic difficulties, yet lots of research suggests it's as effective as any antidepressant drug. To perhaps clarify StratPath's reply, Effexor, Serzone,Wellbutrin and Remeron are not SSRIs. Although Effexor and Serzone are Seratonin Reuptake Inhibitors, they also have other mechanisms of action. I don't know about the return of your depression but there ARE ADs that don't have the loss-of-orgasm side effect: Wellbutrin, Serzone, Remeron. (Ref W S Appleton MD, "Prozac and the new Antidepressants" publ. Jan 1997). I am most certain of Wellbutrin. The other two are much newer, so search for recent studies confirming this for Serzone and Remeron. In general, I'd also like to suggest to anyone with these kinds of questions to get some books or web documents on these subjects, if your doctor can't provide this knowledge (or even if s/he can. No one cares more about your depression and treatment than you do, and depending on who your doctor is you might easily (if you devote the time to it) learn more about the current knowledge of depression pharmacotherapy than your doctor knows.)
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