Aggressive/violent Behavior Due To SSRI's
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I remember seeing a TV documentary about the bad side effects that people had suffered on Prozac . Can anyone send me references of sites, papers, programmes or reports of the negative side effects of SSRI's ?
Answer:
Researchers have also found elevated serotonin levels in alpha males in monkey troops. They also found that the lower the level in the troop hierarchy, the lower the levels of serotonin. I have taken SSRIs for about 6 years. I have found that my episodes with anger are the same as in pre-SSRI days. Anger is a part of depression that for me does not seem to be influenced by SSRIs. There's a very strong and well-documented relationship between serotonin and self-control, including the control of violent impulses towards others or oneself (as in violent suicide). The relationship is positive, that is, it's a lack of serotonin that lessens self-control. Even those alpha males with high serotonin are exhibiting what could be regarded as controlled, productive aggression or assertiveness. In other studies, thin-skinned, antisocial apes that are always flying off the handle and getting their asses kicked typically have physiological signs of low serotonergic activity in their brains. The paradox is that drugs which increase serotonergic activity should sometimes seem to have the effect of making people less self-controlled, not more. Possibly what's happening is that a backlash to the drugs' serotonergic effects has occurred: the brain can adjust to being pushed in one direction by pushing back (e.g. inhibit serotonin reuptake and the autoreceptors on the neurons may signal them to stop firing so much); if you push it too hard, it may push back even harder, to the point that (in this case) serotonergic activity is less than it was to begin with and instead of sleeping better, you sleep worse, instead of eating less, you eat more, instead of being calm, you're obsessive or aggressive, etc., etc. I became very violent on Prozac; just 'flipped out'. You're not alone in this. My psychiatrist admitted that he'd heard of similar reactions from several people on the drug. I have never felt as aggressive as that before, and so unable to control the aggressiveness. This sounds like the effect of stimulants on kids with Attention Defecit Disorder. As it's been explained to me, ADD is caused by depression of the cerebral cortex. And almost all the processing done by the cortex consists of mitigating and controlling the impulses of the old brain. The stimulant drugs work on the cortex, increasing self control. (As I understand it, Freud's "Id" can be said, broadly and metaphorically speaking, to reside in the old brain, and the "Superego" in the cerebral cortex.)
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